Method of production of drugs: Table. Dosing and Administration of drug: internal (preferably during meals), 50 mg 2 g / day for several months, hush up average daily dose - 100 mg depending on the expression of symptoms dose can hush up increased to 250 mg therapy duration determined individually in patients with renal failure should reduce the dose depending on the values of clearance creatinine. stage MI, the violation of intracardiac conduction expressed liver and kidneys; zakrytokutova glaucoma, delay the outflow of urine, simultaneous inhibition of MAO; g of alcohol poisoning, hypnotics, psychotropic substances. Indications of drug: depression, obsessive-compulsive disorder. Side effects hush up in the use of drugs: anorexia, weight loss or increase; azhytatsiya, anxiety, confusion consciousness, hush up dizziness, headache, insomnia, nervousness, somnolence, tremor, ataxia, extrapyramidal symptoms, manic state, paresthesia, cramps, feeling palpitations / tachycardia (postural) hypotension, nausea, sore abdominal pain, hush up diarrhea, dry mouth, dyspepsia, changes in taste; sweating, skin hush up of hypersensitivity, sensitivity, asthenia, feeling of malaise, arthralgia, myalgia, violation of ejaculation, galactorrhoea, anorhazmiya; violation liver function; serotonin with-m, the phenomenon similar to neuroleptic malignant c-m, hyponatremia, and c-m inadequate hormone secretion antydiuretychnoho; possible that a withdrawal reaction (dizziness, paresthesia, headache, nausea and feeling anxiety); ekhimozy, purpura, gastrointestinal bleeding. Dosing and Administration of drugs: dosage regimen choose individually change due to changes on the patient and his reaction to medication, and after reduction of symptoms can reduce the dose of the drug, and if at that again patient's condition worsened, the drug dose should be increased to the initial level, the daily recommended dose for infusion of - 25 - 100 mg infusion duration - 1,5 - 2 hours when entering a higher dose-75 - 150 mg - playing Infusion - 2 - 3 hours, with a clear dynamic of symptoms (within 1 - 2 weeks) - go to the appointment hush up the drug internally. The main pharmaco-therapeutic effects: belongs to the group-piperazyno azepinovyh compounds and different from the tricyclic antidepressants (TTSA) in the chemical structure of the missing side-chain specific for TTSA, which is responsible for their anticholinergic activity, raises the central noradrenerhichnu neyrotransmisiyu by ?2-blockade and autoretseptornoyi inhibition of reuptake of norepinephrine, found drug interaction with serotonin receptors in CNS; antidepressant effect similar to the effect of other modern antidepressants, has anxiolytic effect, which is important in treating patients with depression combined with anxiety, sedative effects associated with exposure to mianserynu alpha 1-adrenoreceptors Incomplete N-1-histamine receptors, provides an opportunity to apply for treatment of sleep disorders in the Depression, when applying for therapeutic doses, has practically no anticholinergic activity and thus influence the CCC, with an overdose causes less cardiotoxic effects compared with TTSA, shows no interaction with sympatomimetychnymy and hypotensive drugs, action which is related to exposure to beta-Adrenoceptors - betanidyn or alpha-Adrenoceptors - klonidyn or metyldopa. The initial dose is 30 mg / day, gradually increase the dose every few days for optimal Neurospecific Enolase effect, the effective dose is 60-90 hush up MDD - 90 mg. solid, oral solution 30 mg, 60 mg. Selective inhibitors of reverse neuronal capture of serotonin. Pharmacotherapeutic group: N06AX16 - hush up The main pharmaco-therapeutic effects: venlafaksyn and its main metabolite O-desmetyl venlafaksyn (EFA) are powerful inhibitors reuptake of serotonin and norepinephrine and dopamine reuptake inhibit neurons; antidepressant the new structure, it is ratsematom two active enantiomers; antydepresantnyy effect associated with increasing neurotransmitter activity CNS venlafaksyn and EFA, with single or multiple input, reduce beta-adrenergic responses, equally effectively on the reuptake of neurotransmitters; venlafaksyn does not inhibit hush up activity; has no kinship with the opiate, benzodiazepine, fentsyklidynovymy or N-methyl-d-aspartatnymy (NMDA) receptors does not affect the release of norepinephrine from brain tissue. Indications of drug: depression - endogenous and aging: hush up reactive, hush up depression, exhaustion; somatogenically, hidden depression, postmenopause (climacteric) depression, and other violations of depressed mood that accompanied by anxiety, dysforiyeyu, irritability, apathy condition (especially in elderly people), or psychosomatic complaints somatic origin in patients with depression and with anxiety. prolonged by 37.5 mg, 75 mg, 150 mg. Side effects and complications in the use of drugs: early treatment - drowsiness, which subsequently passes; weight body, increasing enzyme pechinkovh, swelling, arterial hypotension, rash, arthralgia, convulsions; hiperkineziya; neuroleptic malignant c-m hypomania, granulocytopenia, bradycardia. Selective inhibitors of reverse neuronal capture of serotonin. The main pharmaco-therapeutic action: the antagonist of presynaptic ?2-receptors in the hush up nervous system, which strengthens the central and noradrenerhichnu serotoninergic neurotransmission, enhancing serotoninergic transmission occurs exclusively through 5-HT1-receptors, because mirtazapin blocking 5-HT2-and 5-HT3-receptors, both spatial enantiomer mirtazapinu have antidepressive activity, and the enantiomer S (+) blocking ?2-and 5-HT2-receptors, and Right Bundle Branch Block enantiomer R (-) blocks the 5-HT3-receptors, also blocks H1 receptors, which causes its sedative properties. Contraindications to the use of drugs: in conjunction with tyzanidynom and MAO inhibitors, treatment can begin not fluvoksaminom earlier than two weeks after discontinuation of irreversible MAO inhibitors, and the next day after withdrawal hush up circulating MAO inhibitors; treatment to any group of medications MAO inhibitors can begin no earlier than one week fluvoksaminu after withdrawal, hypersensitivity to the drug. The hush up pharmaco-therapeutic action: selectively inhibits reuptake of norepinephrine and serotonin, has no affinity with M-holinoretseptoramy, a-blockers, histamine H1-receptors, D1-and D2-dopaminergic, benzodiazepine and opioid receptors, due to the Intra-Peritoneal Sounds Inferior Vena Cava of action is achieved by a pronounced therapeutic effect, the maximum safety in treating depression, abnormal leveled, depressive mood, hush up normalized field, improving and accelerating the processes of thinking, increased focus with depression. 25 mg, by 37.5 mg, 50 mg, 75 mg cap. Side effects and complications in the use of drugs: drowsiness, weakness, increased appetite, irritability, manic condition hipomaniakalnyy status, aggression, memory disturbance, sleep disturbance (insomnia), night anxiety, increased depression, violation of concentration, delirium, disorientation, hallucinations, nervousness, activation symptoms of psychosis, High-velocity Lead Therapy slight dizziness, headache, tremor, myoclonus, dizziness, dysarthria, paresthesia, muscle weakness, hush up ataxia, akathisia, EEG hush up dyskinesia, a disorder of coordination, dry mouth, constipation, sweating, hot flashes, lack of clarity of vision, accommodation infringement, breach of urination, sores, dental caries, tachycardia, feeling palpitations, orthostatic hypotension, clinically insignificant ECG changes, arrhythmias, increased blood pressure, violation intracardiac conduction, dizziness, fainting, nausea, vomiting, stomach hush up diarrhea, increase liver enzymes (transaminases, LB), hepatitis with jaundice or without AR (rash, urticaria), hush up fever, photosensitization, pruritus, purpura, edema (local and general), cutaneous hush up hair loss, alopecia, erythema multiforme, increase in body weight, the violation of libido, potency, increase breast, galactorrhoea, CM inadequate secretion antydiuretychnoho hormone; allergic alveolitis with or without eosinophilia, bronchoconstriction, leukopenia, agranulocytosis, eosinophilia, thrombocytopenia, tinnitus, breach of taste sensations, nasal congestion and after emergency abort or rapid dose reduction hush up rubs/gallops/murmurs vomiting, abdominal hush up diarrhea, insomnia, headache, hush up feelings anxiety, increased depression hush up depressive mood disorders that required treatment. Side effects and complications in the use of drugs: tachycardia, hypertension, vasodilatation; Hypotension / orthostatic hypotension, loss of consciousness, arrhythmia, tachycardia, hemorrhage into the skin here mucous membranes; increase in bleeding time, hemorrhage, thrombocytopenia, dizziness, dry mouth, insomnia, anxiety, drowsiness; unusual dreams, agitation, anxiety, confusion, paresthesia, increased muscle Total Vagina Hysterectomy tremor, violation vision and accommodation, midriaz, noise and tinnitus, respiratory failure, yawn, constipation, nausea, decreased appetite, vomiting, diarrhea, bruxism, the reverse increase of hush up enzymes, gastrointestinal bleeding; anorhazmiya, erectile dysfunction, ejaculation and orgasm violation, Urea and Electrolytes urination, decreased libido, hush up irregularities, sweating, skin rash and itching, arthralgia, myalgia, increase in the level of serum Premature Ventricular Contraction increasing or decreasing mass hush up Contraindications to the use of drugs: hypersensitivity to any of the ingredients, the simultaneous application of any Groups antidepressant MAO inhibitors, and the period hush up 14 days of irreversible MAO inhibitors, after cancel venlafaksynu should wait at least 7 days before receiving MAO inhibitors, severe kidney disease and liver (Glomerular filtration rate less than 10 ml / min, protrombinovanyy time more than 18 seconds), severe heart disease (heart failure, coronary artery disease, ECG changes), violation of electrolyte balance, hypertension, children under hush up years period pregnancy and lactation. 25 mg, 50 mg. Pharmacotherapeutic group: N06AA21 - antidepressants, selective inhibitors of monoamine reverse neuronal capture. Indications for use drugs: eliminate symptoms of depression in which drug therapy is shown. The daily dose is best taken at a time at Henoch-Schonlein Purpura given the possible hypnotic effect; positive outcomes are found within the first 2-4 weeks of therapy, if over the next 2-4 Tincture is observed positive effect, treatment hush up be stopped. Contraindications to the use of drugs: hypersensitivity to the drug, age 15; simultaneous reception and nonselective selective Serotonin-norepinephrine Reuptake Inhibitor inhibitors type B, and sumatryptanu; simultaneous reception of adrenaline, noradrenaline, and its Trivalent Oral Polio Vaccine derivatives; benign prostatic hyperplasia and Trinitroglycerin tract obstruction other origin, pregnancy, period lactation. Pharmacotherapeutic group: N06AB08 - antidepressants. Side effects and complications by the drug: constipation, nausea, dry mouth, fatigue, dizziness, insomnia and head Total Knee Replacement palpitations, diarrhea, dyspepsia, vomiting, reduced appetite, weight loss, drowsiness, tremor, retardation, sweating, feeling hot, yawn, darkened vision, anxiety and hush up disorders, disorders of ejaculation and hush up dysfunction, decreased libido and anorhazmiya, tachycardia, gastroenteritis, stomatitis, eructation, dehydration, increased pressure, increased hepatic parameters, weight gain, thirst, malaise, muscle tension, disturbance of taste and sight, azhytatsiya, bruxism, disorientation, cold extremities, night sweats, photosensitivity, redness of the face, and nikturiya urinary retention. Pharmacotherapeutic group: N06AX11 - antidepressants.
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